This book provides an ethnography of street-level policing in the United States and offers an analysis with valuable lessons for today's law enforcement officers. Author George C. Klein, sociologist and former police officer, explores the characteristics of policing in a suburb outside of large Midwestern city in the United States. As a participant-observation fieldworker, he functioned as an ethnographic researcher, recording with a sociological eye the "real world" tasks of policing, including the ordinary as well as the more remarkable aspects of day-to-day law enforcement. He approaches the data with three levels of analysis, looking at embedded issues in policing, such as discretion, danger, corruption, cynicism, race, and class; a mid-range analysis that examines police work as an example of street-level bureaucracy; and a global analysis assessing the entrenched roles of race, class, and demography in police work, as well as, society, in the U.S. This book focuses on the need for police officers to solve social problems that other institutions in society are unwilling, or unable, to solve. It examines a myriad of issues, such as police socialization, the use of force by police officers, stress levels and suicide risk factors, disparate styles of policing, police militarization, de-escalation, and more. With compelling detail, the author helps the reader understand the turmoil regarding policing in the United States today. It is ideal for police professionals as well as students and scholars of criminal justice, criminology, sociology, psychology, history, political science and journalism.

This book provides an ethnography of street-level policing in the United States and offers an analysis with valuable lessons for today's law enforcement officers. Author George C. Klein, sociologist and former police officer, explores the characteristics of policing in a suburb outside of large Midwestern city in the United States. As a participant-observation fieldworker, he functioned as an ethnographic researcher, recording with a sociological eye the "real world" tasks of policing, including the ordinary as well as the more remarkable aspects of day-to-day law enforcement. He approaches the data with three levels of analysis, looking at embedded issues in policing, such as discretion, danger, corruption, cynicism, race, and class; a mid-range analysis that examines police work as an example of street-level bureaucracy; and a global analysis assessing the entrenched roles of race, class, and demography in police work, as well as, society, in the U.S. This book focuses on the need for police officers to solve social problems that other institutions in society are unwilling, or unable, to solve. It examines a myriad of issues, such as police socialization, the use of force by police officers, stress levels and suicide risk factors, disparate styles of policing, police militarization, de-escalation, and more. With compelling detail, the author helps the reader understand the turmoil regarding policing in the United States today. It is ideal for police professionals as well as students and scholars of criminal justice, criminology, sociology, psychology, history, political science and journalism.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.
Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.

This new commentary on Zechariah is a part of the 46-volume New American Commentary series--an acclaimed resource for ministers and Bible students who want to understand and delve more deeply into the Scriptures. Based on the New International Version, the volume exhibits sound methodology reflecting research done in the Scripture's original languages. NIV text printed in the body of the commentary aids in cross-reference and study. Featured at academic conferences, the book is also a publicity focus on top theological blogs and publications. The author is an associate dean for the Research Doctoral Program and an associate professor Southwestern Baptist Theological Seminary in Texas. He also serves on the Old Testament editorial board for the Bulletin for Biblical Research.

The acclaimed primer of electrophysiology - from two leading experts Cardiac Arrhythmias: Interpretation, Diagnosis and Treatment, Second Edition is a practical clinical guide for healthcare professionals who seek a basic knowledge of electrophysiology and how to interpret and treat patients with arrhythmias. One of the main benefits of this book is the author's ability to take electrophysiology and break it down clearly and simply so internists and family practitioners who do not have an extensive background in this complex aspect of cardiology can understand it and its relationship to treating arrhythmias. The Second Edition has been updated to include the latest treatment advances, new and important clinical trials, additional cases, and coverage of new drugs and devices; and is enhanced by full-color tracings, and an increased number of tables and illustrations.

Since its introduction in 2012, cell-free (cf) DNA based Non-Invasive Prenatal Testing (NIPT) has been employed to test for fetal chromosome abnormalities, and gene mutations that lead to a variety of genetic conditions, by millions of pregnant women, in more than 90 countries worldwide. With Noninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and Diagnosis, Dr Lieve Page-Christiaens and Dr Hanns-Georg Klein have compiled the first authoritative volume on cfDNA NIPT methods and their clinical implementation.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including liposome-based chemotherapy and immunotherapy, human polyomaviruses, the role of micro RNAs in CLL, and cancer and cholesterol.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papillomavirus, and modeling prostate cancer in the mouse.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including tumor dormancy, micro RNA, tumor angiogenesis, cancer in mouse models, liposome based chemo and autoimmunotherapy, signaling in angiogenesis, targeted cancer therapy, and regulatory t-cells.

The "Advances in Cancer Research" series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer Immunotherapy.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer. Immunotherapy

Held at the Karolinska Instituet, in Stockholm, Sweden, a recent Nobel Minisymposium, " Molecular Oncology From Bench to Bedside, " marked a very special event the celebration of George and Eva Klein s combined 160th birthdays. To honor this occasion, Volume 97 of Advances in Cancer Research brings together a collection of contributions by their former students, colleagues, and collaborators from the past fifty years dedicated to George and Eva Klein. Over a decade ago, the editors of ACR initiated a subdivision of the series called " Foundations in Cancer Research " to distinguish chapters that reflect extraordinary and historical developments in cancer research this volume of tributes honoring the Kleins bodies of work presented at the minisymposium are especially appropriate for the series and should serve as an important resource for future generations.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, "Molecular Oncology - From Bench to Bedside," held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein's combined 160th birthday. To honor this occasion, this 2nd of two volumes brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called "Foundations in Cancer Research" was initiated and the tributes honoring the Kleins' bodies of work presented at the minisymposium are especially appropriate for the series.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development - Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including NY-ESO-1: review of an immunogenic tumor antigen; Order, disorder, death: lessons from a superorganism; Control of differentiation in progression of epithelial tumors; Cancer vaccines: preclinical studies and novel strategies; Clinical results of vaccine therapy for cancer: learning from history for improving the future; Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell based cancer vaccines; NK cell receptors as tools in cancer immunotherapy; Innate immune recognition and suppression of tumors; Inhibitors of the HSP90 molecular chaperone: current status.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation; Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer; T-Cell Transformation and Oncogenesis by a2-Herpesviruses; Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis; Soluble Mediators of Inflammation During Tumor Development; Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including chromosome instability in cancer; telomerase inhibitors as an option for chemotherapy; avian retrovirus pathogenicity; Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma; immunotherapy for prostate cancer; and the role of lymphocytes in anti-tumor immunity.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including chromosome instability in cancer; telomerase inhibitors as an option for chemotherapy; avian retrovirus pathogenicity; Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma; immunotherapy for prostate cancer; and the role of lymphocytes in anti-tumor immunity.

The Von Hippel-Lindau Tumor Suppressor Complex and Regulation of Hypoxia -Inducible Transcription. Retinoblastoma Tumor Suppressor and Genome Sta bility. The Abl Family Kinases: Mechanisms of Regulation an d Signaling. Cellular Immunity to the Her-2/neu Proto-oncog ene. A New Challenge for Successful Immunotherapy by Tumors That Are Resistant to Apoptosis: Two Complementary Signals to Overcome Cross-Resistance. Cell Volume and Ion Changes During Apopt otic Cell Death. Mitochondria and Apoptosis: New Therapeut ic Targets.

Coordinate Regulation of Translation by the PI 3-Kinase and mTOR Pathway s. Histone Acetyl-Transferases and Deacetylases in the Con trol of Cell Proliferation and Differentiation. Molecular Pathogenesis o f Human Hepatocellular Carcinoma. The Cell Mediated Immune Response to Human Papillomavirus Induced Cervical Cancer: Implications for Immunotherapy. The T-cell Response in Patients with Ca ncer. The Life and Death of a B Cell.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including gene expression in inherited breast cancer, multiparameter analyses of cell cycle regulation in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes, treatment of Epstein-Barr virus-associated malignancies with specific T cells, the role of glycogen synthase kinase-3 in cancer, chronic immune activation and inflammation in the pathogenesis of AIDS and cancer, and molecular biology of Hodgkin's lymphoma.
* Gene Expression in Inherited Breast Cancer
* Multiparameter Analyses of CellCycle Regulatory Proteins in Human Breast Cancer: A Key to Definition of Separate Pathways in Tumorigenesis
* Rho GTPases in Transformation and Metastasis
* The "myc" Oncogene: Marvelously Complex
* Genetic Requirements for the Episomal Maintenance of Oncogenic Herpevirus Genomes
* Treatment of Epstein-Barr Virus-Associated Malignancies with Specific T Cells
* Role of Glycogen Synthase Kinase-3 in Cancer: Regulation Wnts and Other Signaling Pathways
* Chronic Immune Activation and Inflammation in the Pathogenesis of AIDS and Cancer
* Molecular Biology of Hodgkin's Lymphoma